2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140481
    Acid-PEG5-C2-Boc 1309460-29-4 99.57%
    Acid-PEG5-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Acid-PEG5-C2-Boc
  • HY-130541
    Propargyl-PEG2-OH 7218-43-1 99.66%
    Propargyl-PEG2-OH is a PEG-based PROTAC linker can be used in the synthesis of Thalidomide-O-PEG2-propargyl (HY-126458). Propargyl-PEG2-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG2-OH
  • HY-140730
    Thiol-PEG5000-CH2COOH
    Thiol-PEG5000-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Thiol-PEG5000-CH2COOH
  • HY-140135
    PC-Biotin-PEG4-NHS carbonate 2055198-03-1
    PC-Biotin-PEG4-NHS carbonate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    PC-Biotin-PEG4-NHS carbonate
  • HY-130388
    Propargyl-PEG5-NHS ester 1393330-40-9 98.0%
    Propargyl-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG5-NHS ester
  • HY-140731
    TCO-PEG5000-TCO
    TCO-PEG5000-TCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. TCO-PEG5000-TCO is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
    TCO-PEG5000-TCO
  • HY-141020
    Bis-PEG12-acid 2667583-09-5 99.94%
    Bis-PEG12-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bis-PEG12-acid
  • HY-141217
    m-PEG7-alcohol 4437-01-8 98.56%
    m-PEG7-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    m-PEG7-alcohol
  • HY-130447
    Amino-PEG5-amine 72236-26-1
    Amino-PEG5-amine is a PEG-based (5 units) PROTAC linker can be used in the synthesis of PROTACs.
    Amino-PEG5-amine
  • HY-141232
    Decaethylene glycol 5579-66-8 99.13%
    Decaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Decaethylene glycol
  • HY-65039
    Boc-Hyp-OMe 74844-91-0 98.0%
    Boc-Hyp-OMe is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OMe is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-Hyp-OMe
  • HY-W016456
    5-Bromopentanoic acid 2067-33-6 98.0%
    5-Bromopentanoic acid can be used for the synthesis of inhibitors for aminoglycoside resistant bacteria.
    5-Bromopentanoic acid
  • HY-133192
    Bis-propargyl-PEG3 126422-58-0 98.88%
    Bis-propargyl-PEG3 is a PEG-based PROTAC linker used in the synthesis of PROTACs. Bis-propargyl-PEG3 is used in the synthesis of zinc-dipicolylamine (ZnDPA) complexes with antiplasmodial activity . Bis-propargyl-PEG3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Bis-propargyl-PEG3
  • HY-140656A
    Biotin-PEG-Biotin 194920-55-3 99.32%
    Biotin-PEG-Biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG-Biotin
  • HY-130195
    SPDP-PEG4-NHS ester 1334177-95-5
    SPDP-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    SPDP-PEG4-NHS ester
  • HY-130436
    Acid-C2-PEG4-C2-NHS ester 1343476-41-4 98.0%
    Acid-C2-PEG4-C2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Acid-C2-PEG4-C2-NHS ester
  • HY-140069
    endo-BCN-PEG4-NHS ester 2252422-32-3 99.27%
    endo-BCN-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. endo-BCN-PEG4-NHS ester is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    endo-BCN-PEG4-NHS ester
  • HY-133455
    Benzaldehyde-PEG4-azide 1151451-77-2
    Benzaldehyde-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Benzaldehyde-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Benzaldehyde-PEG4-azide
  • HY-133374
    DBCO-PEG12-Maleimide 2962826-52-2 98.0%
    DBCO-PEG12-Maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG12-Maleimide is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG12-Maleimide
  • HY-W003696
    tert-Butyl 5-bromoisoindoline-2-carboxylate 201940-08-1 99.44%
    tert-Butyl 5-bromoisoindoline-2-carboxylate (Tert-butyl 5-bromo-1,3-dihydro-2H-isoindole-2- carboxylate) is a PROTAC Linker. tert-Butyl 5-bromoisoindoline-2-carboxylate can be used in synthesis PTOTAC HSD17B13 degrader 1 (HY-159651).
    tert-Butyl 5-bromoisoindoline-2-carboxylate
PROTAC Linkers Isoform Comparison

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